It can be done with 'Custom Drivers'! (Tools/Devices/Custom Drivers ...)
You can create as many aliases for a driver as you want. Name one 'ASI Color' and another 'ASI Monochrome'. After a restart of KStars you can create two profiles with the respective alias driver name. Start each one seperately and save the configuration. Now you can choose between mono-profile and color-profile with the correct filternames in the slots.