Just had lots of problems connecting to USB and serial devices due to the brltty.services. This is what finally worked for me (Ubuntu Mate 22.04 on RPi4).
sudo systemctl stop brltty-udev.service
sudo systemctl mask brltty-udev.service
sudo systemctl stop brltty.service
sudo systemctl disable brltty.service
you can check these service are inactive/dead by doing
sudo systemctl status brltty-udev.service
sudo systemctl status brltty.service
After doing the above I was able to recognise my arduino based devices and other usb devices.
I also found that you need to install linux-modules-extra-raspi to recognise any arduino uno based devices.