According to the user guide:
Profile: Select which equipment profile to utilize when starting Ekos. If Ekos & INDI are already started and online, this selection is ignored.

Tonight I had 2 crashes in a row starting a Scheduler job that had the profile set to my usual profile by name instead of Default. Ekos was already connected and I saw the log window reporting an attempt to connect devices for the profile nevertheless. After that, KStars crashed. This happened twice.

Only setting the profile in the job to Default I could start. Looks like the selection might not be ignored when ekos is already connected?