It is possible if you have a camera with non-destructive readout.
We don't have that.
Think of it like this: If you have short enough exposure times that you - can- guide with your imaging camera, you -don't have to-, because the tracking error would be negligible in that case.
Best is to simply get a guide scope or off-axis guiding. Personally, I prefer a separate, light weight guide scope, because it's more light sensitive and it prevents issues with vignetting on the imaging camera. Also I already have a lot of weight on the focuser.