I think I have the same cam model (cooled imx571 Color) - what works for me is to leave the usb setting at 2 and timeout >6. The cam is connected to usb3 of pi4 with cooling and fan active. Other than that pi is used only to run drivers and occasionally phd - all pictures are loaded up to my client computer via 1gb cable Ethernet.I had occasionally timeouts but the above removed them and now it happens very seldom, and never for calibration frames. Also, the driver description says it is sensitive to power fluctuations, so make sure the power supply works fine with enough power if you use the usb hub on the cam.

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