Did you wait for astrometry to conclude target position was within tolerance? If not it was still working on centering the star, ambivalent to your choice of a new target.
Next time either wait for it to finish getting on target, or only sync mount, or cancel after the first solve.
INDI/KStars on Raspberry Pi 4, 4gb
Raspbian Buster with AstroPi3 script configuration
Skywatcher HEQ5 Pro Mount
Canon 600D Camera
Orion SSAG/ASI120mm @280mm Guide Scope
Adafruit Motor Hat shield
Adafruit GPS Module
Generic Bluetooth Joystick.
Startech 7 port powered USB Hub.
I run my initial autofocus while parked with the scope pointing at the North Celestial Pole. Then just tell the solver to capture and solve my intended target.
There must also have been significant improvements on the focus module since last year. It no longer attempts to measure the galactic core, which always was problematic. Auto Star now picks stars surrounding M31. The image is in perfect focus afterwards.
One more thing that has helped me: Don't overexpose when focusing. If the stars are saturated, focus will suffer. A standard setting for me is 240 gain on the ASI1600MM using Luminance filter and 1-3 s exposure time.
Atlas Pro AZ-EQ, ASI1600MM-Pro, ASI120MM-S, ES102ED, WO-Z61, Nikon D3300, ASI-EFW, ZWO LRGB,Ha,O3,S2 filter set
I just bought the Rigel focuser, but did not test yet.
Gain means ISO number?
ISO 250 is very low gain, but I can understand it is helpful when focusing.
I do not have Luminance filter. I have Sony A7s DSLR, but should be the same values.
10" Meade SC Telescope on Skywatcher NEQ6 Pro Mount
Starlight Xpress X2 Autoguider
Sony Alpha 7s DSLR Camera
INDI on Stellar Mate with Kstars/Ekos